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In mice, a series of experimental studies with the infected virus were carried out and after melatonin administration the disease onset was delayed with reduced mortality rate as the viral load decreased in brain and blood (Bonilla et al

These effects vary in severity depending on the method of consumption, the individuals tolerance, and the amount used

, Reference Ma2011)

Results NAD + metabolites regulate skin oxidative stress and inflammation In order to determine if NAD + metabolism has any role in the regulation of skin inflammation, we decided to perform functional experiments in the transgenic zebrafish line lyz : dsRED , which labels neutrophils