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Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count

Product Verification This product (Bacteriostatic Water for Injection USP, Hospira, NDC 0409-3977-03) is manufactured by Hospira Inc., a Pfizer subsidiary, and is subject to FDA oversight and USP standards

This blend combines BPC-157 (pentadecapeptide gastric protein derivative) and TB-500 (Thymosin Beta-4 analogue) at equal concentrations (5mg each)

The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained