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Electronic databases including PubMed, Web of Science, Scopus, and Google Scholar were systematically searched from inception through June 2024

In de novo hypothyroid adults without cardiac disease, total daily doses of 20-25 mcg divided two or three times achieve physiologic free T3 levels for most patients

The results of this experiment also indicated that the mTOR pathway has the ability to modify the activity of hormones, such as leptin, which helps control body weight by regulating hunger and food consumption, as well as lipolysis, energy consumption and body temperature (113)

Use of milnacipran has not been evaluated in patients with cardiac rhythm disorders