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Insulin resistance, as well as the conditions of hyperinsulinemia, hyperglycemia, and elevated free fatty acids, play a substantial role in causing injury to cardiomyocytes, deteriorating their functionality, and leading to myocardial lipotoxicity in individuals with diabetes [88]

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The enzymatic conversion pathway from L-tyrosine to dopamine involves tyrosine hydroxylase as the rate-limiting step, which the body can regulate based on physiological demands [4]

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