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Description
Published safety data shows negative results in repeated-dose toxicity studies, skin irritation protocols, sensitization assays, and genotoxicity testing

These results indicate that the PGI2 receptor is located in spinal neurons, and that PGI2 from endothelial cells could affect spinal neurons after peripheral nerve injury

One patient with AR-GTPCHD experienced worsening of depression [26], and one patient with SRD had akathisia and dyskinesia/myoclonus while treatment concurrently with a MAO inhibitor (selegiline) [104]
Young ICH patients were more likely to be male, less likely to have hypertension, heart disease and diabetes, but more likely to have higher body mass index, be current smokers or alcohol users, and with greater hematoma volume
