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Preclinical and clinical studies have shown that the BDNF Val66Met polymorphism is associated with an impaired fear extinction process and increases the risk for anxiety disorders and PTSD (Felmingham et al., 2018
Therefore, this metabolic microenvironment of solid tumors can be recapitulated, and throughout the study we used 0.5 mM glucose in media to recapitulate glucose deprivation and, on top of this, added 20 mM lactic acid for a mimicry of lactic acidosis
It is vital to the production of ATP
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