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AMP Kinase (AMPK): AMPK, a key energy-sensing kinase, modulates the activity of glutamine-PRPP amidotransferase to ensure that nucleotide synthesis is in sync with cellular energy status

Roxburgh CSD, Strombom P, Lynn P, Cercek A, Gonen M, Smith JJ , Temple LKF, Nash GM, Guillem JG, Paty PB, Shia J, Vakiani E, Yaeger R, Stadler ZK, Segal NH, Reidy D, Varghese A, Wu AJ, Crane CH, Gollub MJ, Saltz LB, Garcia-Aguilar J, Weiser MR

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Mitochondria-targeting drugs can trigger ICD by releasing ROS and other DAMPs, which can promote DC maturation, activate cytotoxic T lymphocyte, and reverse immunosuppression in the tumor microenvironment