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Elevated levels of MNAM were detected in the urine (Li et al., 2018) and serum (Souto et al., 2005) demonstrated an upregulation of NNMT expression in the WAT of individuals with IR or T2D

The health outcomes range from increased risk of premature death to serious chronic conditions that reduce the overall quality of life [1]

This will subsequently form complexes with the cobalmin and thereby reduce its efficacy

PRESCRIPTIVE B12 VERSUS NON PRESCRIPTIVE B12 PRESCRIPTION B12 Hydroxocobalamin NICE-recommended form used by the NHS Prescribed by a GMC or NMC-registered medical practitioner Medical consultation required your safety is assessed first Same clinical standard as your GP Longer-lasting and more stable in the body No cyanide content Administered by a qualified medical professional using correct technique Monitored and reviewed protocol adjusted to your individual needs Private blood testing available to confirm deficiency and track response Legal, compliant and fully documented prescription NON-PRESCRIPTION B12 Often cyanocobalamin cheaper synthetic form not recommended by NICE Not prescribed no prescriber involved No medical consultation or safety assessment required Not the same standard as your GP Shorter-acting and less stable Contains a small amount of cyanide the body must detoxify Administered by non-medical staff with no clinical oversight No monitoring, no review, no adjusted protocol No blood testing deficiency not confirmed No legal prescription grey area of compliance VITAMIN B12 FAQS Vitamin B12 Injection FAQs What is the difference between hydroxocobalamin and cyanocobalamin