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Description
IGF-1 signaling disruption determines macrophage activation into the pro-inflammatory M1 phenotype and reduces lipid efflux, promoting lipid accumulation in macrophages (119, 147)
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IL18, interleukin-18
The photooxidation of A2E through blue light can lead to several modifications that include DNA base lesions, lipid peroxidation of proteins, advanced glycation end-products (RAGE), proteasome stress, and ubiquitin accumulation
