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In brief, mitochondrial fission and fusion are tightly regulated by a complex protein machinery involving DRP1, MFN1, MFN2, and OPA1 in mammalian cells

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Kemp M, Go YM, Jones DP: Non-equilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology

however, some xenobiotics, ionizing radiation, illnesses, or aging may cause the production of ROS to levels that exceed the neutralizing capacity of an organism, thus leading to a series of pathological changes, which in turn leads to oxidative stress
