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Description
He traced the effect to this small copper-binding peptide and launched five decades of research

doi: 10.34172/apb.2024.009

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
GSH protects mitochondria via the glutathione-ascorbate cycle, also known as the Asada-Halliwell pathway [22], which is the main pathway to neutralize the hydrogen peroxide radicals created as a byproduct of normal metabolism
