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These observations underscore the involvement of the hypoxic microenvironment in MS-associated vascular pathology, implying that strategies aimed at improving vascular oxygenation, mitigating immunoinflammatory damage, downregulating vasoactive substances, and reversing vascular abnormalities may reduce ischemic damage to the skin and visceral organs

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However, this therapeutic approach has its limitations

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Neuroscience 94 , 937948 (1999)

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[DOI] [PubMed] [Google Scholar] 71.Zhang C, Li YS, Li JY, Chen X (2020) Total thyroidectomy versus lobectomy for papillary thyroid cancer A systematic review and meta-analysis

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