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Funding We would like to acknowledge NSFC (31902196), Science and Technology Projects of Hunan Province (2019RS3020), the earmarked fund for China Agriculture Research System (CARS-35), China Postdoctoral Science Foundation-funded project (2021M693383, 2019M662273), and Taisha industry leading talent blue talent project for their financial support

Hypoxia and ferroptosis Hypoxia was shown to be a normal feature of tumors and occurs within around 90% of tumors, promoting tumor progression and antagonism to treatment [186,187,188]

Ammonia accumulation is closely associated with protein synthesis and degradation processes (106, 108)

Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens