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Proc Natl Acad Sci USA 101:24702475 Ronaldson PT, Bendayan R (2008) HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells
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Mechanistically, loss of the PUFA -oxidation enzyme 2,4-dienoyl-CoA reductase 1 increases cellular PUFA burden, elevates phospholipid hydroperoxides, and triggers ferroptotic death in cancer models 345
Additionally, Dutkiewicz et al
