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Beyond using sertraline in combination with radiotherapy as a therapeutic strategy for ser/gly synthesis dependent cells in normoxia, the hyperactivation of ser/gly synthesis enzymes under hypoxia in NSCLC also suggests the potential of sertraline to target hypoxic cells relying on ser/gly synthesis (Figure S11)

30788612 Morales-Vidal SG

Recommendations for mitigating adverse effects were formulated based on the analysis of injection practices, including modifications to dosage, injection-site distribution, and volume

This knowledge collectively suggests the presence of a complex regulatory framework 127 , which emphasize that the regulation of PHD activities within the intracellular environment is reliant on a diverse range of factors, rather than being exclusively governed by -KG