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There are convincing literatures supporting the role of T lymphocyte perturbation in SLE patients
Additionally, hypermethylation of the Foxp3 gene promoter in T cells results in reduced Foxp3 expression, impairing Treg cell function and disrupting immune homeostasis, thereby exacerbating MS progression (83, 85)
J Clin Invest (2005) 115:162735
Interaction between the non-catalytic cysteine at position 129 and the catalytic cysteine 227 shows the formation of a disulfide bond, which maintains its catalytic activity (91, 92)
