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GSH deficiency or a decrease in the GSH/glutathione disulfide (GSSG) ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in diseases such as cancer, Parkinsons disease, and Alzheimers disease

Clinical effects of hydrogen administration: from animal and human diseases to exercise medicine

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Pedrini N., Ortiz-Urquiza A., Huarte-Bonnet C., Fan Y., Jurez M.P., Keyhani N.O

GSEA analysis revealed significant enrichment of IFN-I signaling pathways in the Lig group (Fig S6a), while the corresponding heatmap analysis confirmed upregulation of IFN-Iresponsive genes in Lig-derived neutrophils (Fig S6b)