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MEDI-547, an ADC composed of a human anti-EphA2 monoclonal antibody linked to the monomethylauristatin F payload, showed substantial antitumor activity in mouse models
Its main function is to regulate levels of hydrogen peroxide and peroxidation of ethanol to acetaldehyde in the presence of H2O2 (51)
The concomitant reduction in coronary resistance at these time points further supports enhanced vascular relaxation and suggests attenuation of endothelial injury in GSNO-treated heart
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