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EGFR also induces ERK2 to phosphorylate PKM2 at Ser 37, which allows peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) to bind to PKM2, prompting PKM2 to translocate to the nucleus, upregulating lactate dehydrogenase A (LDHA) and glucose transporter 1 (GLUT1) expression and promoting the Warburg effect (Yang et al., 2012b)
These studies validate the role of TCM in PD therapy and guide future research and drug development
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To, L., Villarreal, L
