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The basolateral membrane PTH-1 receptor binds the PTH present in the blood circulating through the peritubular capillaries

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However, in acute ischemia-reperfusion models, overexpression of HIF-1 can reduce pyroptosis markers (e.g., GSDMD cleavage products) and the release of IL-1 and IL-18 by inhibiting the ROS/NLRP3 pathway in microglia

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Production of superoxide anions by a CNS macrophage, the microglia

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