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NAC at doses exceeding 1,800mg daily can theoretically deplete copper and zinc over months of continuous use, but standard dosing (6001,200mg daily) poses no nutritional depletion risk when combined with adequate dietary intake

PD mainly occurs due to the degeneration of dopamine-generating neurons in the substantia nigra

Only 10% of patients with Hartnup disease have clinical evidence of protein deficiency (i.e., pellagra) commonly associated with defects in protein or amino acid absorption

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