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L-Carnitine Supplementation for the Management of Fatigue in Patients with Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial

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The high ROS environment lowers the activation threshold of mast cells, causing them to degranulate inappropriately and release a flood of inflammatory cytokines, including histamine, interleukins, and tumor necrosis factor-alpha (TNF-a)

doi: 10.1016/j.jpainsymman.2006.09.001 35 HolckAWolkowitzOMellonSReusVNelsonJWestrinet al