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Description
Sphingosine kinase 2 (SPHK2) is also required for the autophagy-mediated catabolism of intracellular LDs to prevent the development of atherosclerosis by reducing sphingosine content in macrophages (Ishimaru et al., 2019)
As demonstrated by its ranking first among the top five most prevalent five-membered nonaromatic nitrogen heterocycles and its presence in thirty-seven new molecular and/or first-in-class entities approved by the FDA, such as captopril, lincomycin, clemastin, and remoxipride, the pyrrolidine nucleus is one of the preferred scaffolds in pharmaceutical sciences and drug design
Hichri et al., 2011
Further research into Hh pathway dysregulation could pave the way for more effective, targeted therapies for GBM management
