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Description
Under normoxic conditions, the TCA cycle proceeds oxidatively from pyruvate to citrate, succinate, fumarate, malate, and finally oxaloacetate
Initiator caspases possess a longer N-terminal pro-domain structure that enables them to form a protein platform that regulates caspase activation, such as the interaction between the pro-domain of caspase-9 and Apoptotic Protease-Activating Factor 1 (APAF-1) along with cytochrome c (Cyt c), which initiates apoptotic bodies [86]
Purine and glutamate metabolism were the top hits, suggesting perhaps ATP and glutathione biology are impacted
Wastl et al
