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Tumor cells selectively take up more vitamin C compared to normal cells through an upregulated metabolic need for glucose due to similarities between Vitamin C and Glucose (Agus 1997)

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In order to test this hypothesis, the group synthesized 2-[[2-[4-(3-oxo-1,2-benzoselenazol-2-yl)phenyl]acetyl]amino]ethyl-triphenyl-phosphonium chloride (mitoperoxidase 2) derivative and evaluated its efficacy for ameliorating radiation toxicity in cellular and mice models (Table 2) (Fig