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It is essential for target-directed degradation of miR-7 in cells, as measured using a reporter assay that provides a fluorescent readout of cellular miR-7 activity 10 after rescue of ZSWIM8 -knockout cells with a wild-type (WT) or variant ZSWIM8 transgene of interest (Extended Data Fig

These cells are directly related to tissue damage, increased inflammation, and increased cancer risk

The IRS1/Akt pathway is critical for regulation of metabolism by insulin and InsR