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This reduces risks as well as ensures that results are watched closely

Wiley Sunspots (or solar lentigines) are small, darkened spots on the skin caused by excessive exposure to UV

However, contrary to expectations, the deletion of the Nfe2l2 gene had a moderate impact on the course of the disease in SOD1 G93A mice and negatively affected only a few Nrf2-regulated antioxidant enzymes, thus suggesting that several Nrf2-target genes can also be regulated independently of Nrf2 in ALS mice [270, 271]

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