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doi: 10.3390/biom13030546

In the fifth edition of the World Health Organization (WHO) classification of digestive system tumors [2,3], there is a chapter on mesenchymal tumors

Although the main function of mitochondria is energy production, they are also involved in cellular detoxification, cellular stabilization, as well as control of ketogenesis and glucogenesis

The inability to adapt to the different cellular and environmental needs/stressors results in metabolic inflexibility, which ultimately leads to disease states like insulin resistance, lipid accumulation, and an inability to maintain homeostatic balance [24,25,26] (Figure 6)