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In the lungs of mice exposed to cigarette smoke, altered rhythms of SIRT-1 protein and core clock genes including Bmal1, Clock, Per1, Per2, Cry1, Cry2, Nr1d1, Nr1d2 , and Rora were observed in a circadian manner, increasing the susceptibility to inflammation and emphysema development (58)

This increased expression mediates enhanced intracellular glutamate efflux, leading to increased glutamine dependence and heightened sensitivity to glutaminase inhibition in cancer cells

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