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In resistant cases, by comparison, two distinct failure modes emerge, in which either terminally exhausted T-cell clones prevail and exhibit restricted stem-like potential and epigenetic fixation into dysfunctional states that impair immediate effector function or the memory precursor pool contracts, leading to loss of long-term immune surveillance

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doi: 10.3390/biom13101512 15 BokoviM.VovkT.Kores PlesniarB.GrabnarI