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However, no controlled trials support these claims in humans

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Comparison with growth hormone secretagogues Peptides like ipamorelin and CJC-1295 increase growth hormone release, which influences tissue regeneration throughout the body

Thus muscle derived FGF21 in Cpt1b m/ mice could have anti-inflammatory action locally in the presence of intracellular toxic lipids, and on adipose or possibly other tissues by circulation contributing to the improvement in inflammatory status at the face of constantly elevated systemic lipids
