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The nephrotoxic potential of certain botanical compounds presents particular concern: aristolochic acid-containing herbs have been definitively associated with progressive tubulointerstitial nephritis and urothelial carcinogenesis, necessitating absolute contraindication in renal disease contexts (Dickman et al., 2023)

Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus

As observed, eleuterol glucuronide showed higher affinity with this target