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Additionally, rare deficiencies of glutathione cycle enzymes (gamma-glutamylcysteine ligase, glutathione synthetase, 5-oxoprolinase, and gamma-glutamyl transferase) have all been associated with neuropsychiatric and cognitive impairments, although detailed phenomenological characterization has not been reported (9, 61, 62)

Regulatory Status in 2026 Despite growing interest in the compound, GHK-Cu is not an FDA-approved therapy for any health issue

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Milk Thistle Silymarin, a flavonoid extract from milk thistle ( Silybum marianum ), has been shown to counteract the negative impact of estrogen on bile flow in rats (Crocenzi 2001)