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G-Protein-Coupled Receptors and Ischemic Stroke: a Focus on Molecular Function and Therapeutic Potential

Heme deficiency activates HRI, which phosphorylates eIF2, thereby inhibiting translation of globin mRNAs

Thus, two main conclusions can be drawn: first, the degree of receptor phosphorylation is not necessarily directly proportional to the strength of desensitization (Alcntara-Hernndez et al., 2017)

J Drug Deliv Sci Technol 84:104473
