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The enzymatic oxidation of dopamine generates ROS and dopamine quinones, which can react with cellular proteins, lipids, and nucleic acids, causing oxidative damage
A study evaluating homocysteine-induced ER stress in human hepatocytes found activation of the unfolded protein response (UPR) and the sterol regulatory element-binding proteins sterol regulatory element-binding proteins (SREBPs) [85]
As an example, one form of ADH (encoded by the ADH7 gene) is responsible for the metabolism of not only ethanol but also retinol to retinaldehyde which is the form of vitamin A necessary for vision
doi: 10.1002/bip.20254
