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Insufficient melatonin synthesis may contribute to poor sleep at night, fatigue during the day, and changed pain perception [41]

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showed that topical glutathionecyclodextrin (GSH-CD) increased intracellular GSH in mononuclear and red blood cells, decreased malondialdehyde (MDA), and significantly upregulated immune cytokines including IL-2, IFN-, IL-12p70, and TNF-