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Many supplements use cyanocobalamin the cheapest and most common form of B12 but this synthetic version must be converted by the liver before the body can actually use it

doi: 10.1097/NRL.0b013e3181ebe59f
In a study by Du et al., several new 9-phenanthranilamide derivatives were synthesized and evaluated for their anti-inflammatory and antioxidant activities (109)

Over the full week between doses, total exposure is comparable
