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In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine

This study revealed that mice administered with capmatinib along with anti-PD-1 exhibited extended survival rates compared to those given either capmatinib or anti-PD-1 alone

As the field advances toward personalized medicine, single-cell transcriptomics has revealed interindividual variability in neuronal glycolysis-oxidative phosphorylation balance (e.g., differential GLUT1/4 expression affecting substrate selection in APP/PS1 mice), offering new strategies for targeting AMPK-mediated astrocyte glycogenolysis to optimize neuronal energy supply (Wu et al., 2024)