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Ko et al., 2007
Dose: 2mg twice daily (4mg total) Frequency: Morning and evening Duration: 4-6 weeks maximum Rest period: Equal to cycle length Splitting doses maintains more stable plasma levels throughout the day
When the particle size becomes smaller, the surface area, surface energy and surface binding energy of nanomaterials increase rapidly, and the percentage of surface atoms increases significantly
doi: 10.1016/j.drugalcdep.2018.01.035 35 KotovR.GamezW.SchmidtF.WatsonD
