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A randomized, double-blind, placebo-controlled trial in 88 patients with sepsis and elevated blood concentrations of lactate reported that intravenous thiamin (200 mg twice daily for seven days or until discharge from the hospital) did not decrease lactate concentrations at 24 hours post initiation of treatment the primary endpoint of the trial (104)

Because YC-1 is an sGC activator, it has been suggested that CHAC1 is induced through the sGC-cGMP-PKG signaling pathway

Sawada Y, Honda T, Nakamizo S, Otsuka A, Ogawa N, Kobayashi Y, et al

Genome-wide association study of cadmium accumulation at the seedling stage in rapeseed ( Brassica napus L.)
