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Description
S conformation and assembly state influence cytotoxicity such that shifting the levels of physiological -helical tetramers toward the more aggregation-prone monomers leads to S cytoplasmic inclusions, hyperphosphorylation, and neurotoxicity 42,43,51,52
Subsequently, the affirmative C=C position diagnosis is easily achieved by the diagnostic ions generated via CID in negative ion mode
Investigated for MC4-mediated appetite suppression and body-weight effects in preclinical models
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