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Thus, while not all the metabolic fates of glutamine require glutaminase activity, this enzyme is essential to the metabolic phenotype of growing tumors

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This process ultimately triggers aging-related events, including the secretion of senescence-associated secretory phenotype (SASP) factors like IL-6 and IL-8 by aging cells, which are strongly correlated with histopathological features [77]

At this point, a doctor can perform testing to assess a patients symptoms and their severity