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It is also important to note that LAC levels are decreased in obese subjects [63], emphasizing the need for future studies aimed at exploring a possible link between LAC metabolism and obesity in subjects with MDD

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Therefore, to identify the role of NF-B and the regulative mechanism between GPX1 and NF-B in SGNs damage induced by peroxynitrite, we measured the NF-B pathway in SGNs after peroxynitrite administration with GPX1 upregulation or deficiency (Figure 8A)