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These subjective improvements are commonly reported and can be meaningful for daily functioning
Apr 2018;16(4):634-645
381,382 A large, randomized, placebo-controlled trial found canakinumab had beneficial effects in high-risk patients
Similarly, B12 is classified not for its chemical nature (a vitamin) but for the high-risk administration route (injection) and the severity of the condition (Pernicious Anaemia) it treats
