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Glutathione and the related enzymes belong to the defense system protecting the eye against chemical and oxidative stress

Co-expression network reveals the potential relationship between glutathione with DEGs and DEMs In addition to core genes and metabolites of glutathione metabolism KEGG pathway, 6 DEGs ( cgs1 , 100381533 , bHLH11 , AR7 , OHP2 , MatE, abc1 ) and 5 DEMs (1,3-Benzodioxol-5-yl(oxo)acetic acid, dihydroplumbagin, 6-(2-methoxy-Z-vinyl)-7-methyl-pyranocoumarin, (7R)-(+)-Lyoniresinol 9-glucoside, and Capsanthin-3,6-epoxide) derived from co-expression network those were potentially involved in glutathione metabolism

The ventral tegmental area (VTA), the nucleus accumbens (NAc), and the prefrontal cortex (PFC) all contain GLP-1 receptors