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Br J Cancer 84 : 1118 Ford HER, Mitchell F, Cunningham D, Farrugia DC, Hill ME, Rees C, Calvert AH, Judson IR, Jackman AL (2002) Patterns of elevation of plasma 2-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331

[1] In the SURMOUNT-1 clinical trial, higher doses in non-diabetic adults demonstrated significant weight loss, with participants losing approximately 15-20% of body weight over 72 weeks

Pharmacologic anti-inflammatory therapy is reserved for selected patients and should be considered only by a qualified clinician who can weigh cardiovascular benefit against infection, gastrointestinal, kidney, liver, bleeding, and medication-interaction risks