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Stones larger than 10 mm or that do not respond to conservative treatment may be treated with lithotripsy, ureteroscopy, or rarely, open surgery (Antonelli 2015)

Biomarker guidance (Prx redox state, GSH/GSSG, LIP assays, cysteine-oxidation proteomics, compartment-targeted reporters) helps titrate dose, route and timing, minimizing off-target effects and avoiding the common pitfall of trading one pathology for another by over-suppressing beneficial stress responses (Murphy et al

Alternative Therapies in Health and Medicine , 30 (10), 1217

If you want to build a multi-compound approach, cagrilintide is the more flexible building block