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There are specific scenarios where combining these two forms of B12 might be considered, as part of a tailored treatment plan: Reducing Injection Frequency: For some individuals who require lifelong B12 due to malabsorption but dislike frequent injections, a doctor might explore if high-dose oral supplements can help maintain adequate levels between less frequent injections

The good news is that vitamin B12 is safe, even in large doses

Standard doses work for many, but some need adjustments
