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Pre-weaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels

Arthritis Rheumatism 64 , 16971707 (2012)

This compound disrupts normal metabolic processes in bladder epithelial cells, inhibits DNA repair enzyme activity, and promotes the accumulation of base mismatches in DNA, ultimately resulting in mutations and cancer development (Muenyi et al., 2015

The IDH1 is a homodimeric enzyme encoded by the IDH1 gene located on chromosome 2q33.3 and is composed of 12 exons that generate three alternatively spliced mRNAs, all of which encode the same 414 amino acid protein