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In addition, Pycnogenol plus nattokinase-treated subjects had a 15% reduction in edema at the end of the flight versus a 12% increase in edema in the placebo group
Cerebral spinal fluid (CSF) is considered the appropriate surrogate to evaluate cerebral CoQ10 status, and in view of the low levels of CoQ10 present in this matrix, only highly sensitive analytical techniques such as HPLC-ED and tandem mass spectrometry are appropriate for this analysis [60]
